Cargando…

The development of a rapid patient-derived xenograft model to predict chemotherapeutic drug sensitivity/resistance in malignant glial tumors

BACKGROUND: High-grade gliomas (HGG) are aggressive brain tumors associated with short median patient survival and limited response to therapies, driving the need to develop tools to improve patient outcomes. Patient-derived xenograft (PDX) models, such as mouse PDX, have emerged as potential Avatar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Charbonneau, Martine, Harper, Kelly, Brochu-Gaudreau, Karine, Perreault, Alexis, Roy, Laurent-Olivier, Lucien, Fabrice, Tian, Shulan, Fortin, David, Dubois, Claire M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479744/ https://www.ncbi.nlm.nih.gov/pubmed/36821432 http://dx.doi.org/10.1093/neuonc/noad047

Ejemplares similares

Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion
por: Brochu-Gaudreau, Karine, et al.
Publicado: (2022)

The Chicken Chorioallantoic Membrane Tumor Assay as a Relevant In Vivo Model to Study the Impact of Hypoxia on Tumor Progression and Metastasis
por: Harper, Kelly, et al.
Publicado: (2021)

Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing
por: Charbonneau, Martine, et al.
Publicado: (2022)

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts
por: Almstedt, Elin, et al.
Publicado: (2021)

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
por: Koessinger, Dominik, et al.
Publicado: (2023)

RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo
por: Hendruschk, Sandy, et al.
Publicado: (2011)

Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma
por: Krausert, Sonja, et al.
Publicado: (2022)

Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts
por: Porath, Kendra A, et al.
Publicado: (2022)

HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion
por: Arsenault, Dominique, et al.
Publicado: (2013)

Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)
por: Lucien, Fabrice, et al.
Publicado: (2011)

Incidence trends in pediatric central nervous system tumors in Canada: a 15 years report from Cancer and Young People in Canada (CYP-C) registry
por: Larouche, Valérie, et al.
Publicado: (2020)

Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma
por: Chan, Tiffany S Y, et al.
Publicado: (2021)

Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression
por: Blomquist, Mylan R, et al.
Publicado: (2020)

Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers
por: Verploegh, Iris S C, et al.
Publicado: (2022)

Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma
por: van Kessel, Emma, et al.
Publicado: (2022)

BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma
por: Gusyatiner, Olga, et al.
Publicado: (2021)

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy
por: Belcaid, Zineb, et al.
Publicado: (2020)

Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy
por: Livermore, Laurent James, et al.
Publicado: (2019)

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures
por: Verheul, Cassandra, et al.
Publicado: (2021)

Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival
por: Laurent, Danny, et al.
Publicado: (2021)

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
por: Johansson, Mikael, et al.
Publicado: (2013)

VCAM-1 targeted alpha-particle therapy for early brain metastases
por: Corroyer-Dulmont, Aurélien, et al.
Publicado: (2020)

Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma
por: Pereira, Victor, et al.
Publicado: (2021)

Experimental glioma with high bHLH expression harbor increased replicative stress and are sensitive toward ATR inhibition
por: Koch, Marilin Sophia, et al.
Publicado: (2020)

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice
por: Jan, Hsun-Jin, et al.
Publicado: (2010)

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice
por: de Groot, John F., et al.
Publicado: (2010)

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells
por: Kim, Ella L., et al.
Publicado: (2010)

Genetic variations in EGF and EGFR and glioblastoma outcome
por: Sjöström, Sara, et al.
Publicado: (2010)

Activation of the Hedgehog pathway in pilocytic astrocytomas
por: Rush, Sarah Z., et al.
Publicado: (2010)

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
por: Ostertag, Derek, et al.
Publicado: (2012)

Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile
por: Hägerstrand, Daniel, et al.
Publicado: (2011)

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion
por: Hussein, Deema, et al.
Publicado: (2011)

Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma
por: McCabe, Martin G., et al.
Publicado: (2011)

CRN2 enhances the invasiveness of glioblastoma cells
por: Ziemann, Anja, et al.
Publicado: (2013)

Functional role of endothelial adhesion molecules in the early stages of brain metastasis
por: Soto, Manuel Sarmiento, et al.
Publicado: (2014)

Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways
por: Bernhart, Eva, et al.
Publicado: (2014)

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer
por: Andersson, Ulrika, et al.
Publicado: (2014)

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
por: Merz, Felicitas, et al.
Publicado: (2013)

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
por: Liu, Shie-Chau, et al.
Publicado: (2014)

NCoR controls glioblastoma tumor cell characteristics
por: Heldring, Nina, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cm4v5l6n7blo4anflfca8qq5po