Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can form during transcription. Why INO80 prefers hexasomes over nucleosomes remains unclear. Here, we report structures of S. cerevisiae INO80 bound to a hexasome or a nucleosome. INO80 binds the two substrates in sub...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Muñoz, Elise N., Hsieh, Laura J., Chio, Un Seng, Gourdet, Muryam A., Narlikar, Geeta J., Cheng, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480058/
https://www.ncbi.nlm.nih.gov/pubmed/37384669
http://dx.doi.org/10.1126/science.adf4197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480058/
https://www.ncbi.nlm.nih.gov/pubmed/37384669
http://dx.doi.org/10.1126/science.adf4197

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