Olaparib Attenuates Demyelination and Neuroinflammation in an Organotypic Slice Culture Model of Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is a severe demyelinating, autosomal recessive genetic leukodystrophy. The disease is underpinned by mutations in the arylsulfatase A gene (ARSA), resulting in deficient activity of the arylsulfatase A lysosomal enzyme and consequential accumulation of galactosylce...

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Detalles Bibliográficos
Autores principales: Mekhaeil, Marianna, Conroy, Melissa Jane, Dev, Kumlesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480139/
https://www.ncbi.nlm.nih.gov/pubmed/37525026
http://dx.doi.org/10.1007/s13311-023-01409-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480139/
https://www.ncbi.nlm.nih.gov/pubmed/37525026
http://dx.doi.org/10.1007/s13311-023-01409-w

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