HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics

HIV-1 protease is essential for the production of mature, infectious virions and is a major target in antiretroviral therapy. We successfully purified a HIV-1 subtype C variant, L38↑N↑L(− 4), containing an insertion of asparagine and leucine at position 38 without the four background mutations - K20...

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Detalles Bibliográficos
Autores principales: Sheik Ismail, Zaahida, Worth, Roland, Mosebi, Salerwe, Sayed, Yasien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480237/
https://www.ncbi.nlm.nih.gov/pubmed/37421557
http://dx.doi.org/10.1007/s10930-023-10132-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480237/
https://www.ncbi.nlm.nih.gov/pubmed/37421557
http://dx.doi.org/10.1007/s10930-023-10132-6

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