First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults

BACKGROUND AND OBJECTIVE: MHV370, a dual antagonist of human Toll-like receptors (TLR) 7 and 8, suppresses cytokines and interferon-stimulated genes in vitro and in vivo, and  has demonstrated efficacy in murine models of lupus. This first-in-human study aimed to evaluate the safety, tolerability, p...

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Detalles Bibliográficos
Autores principales: Shisha, Tamas, Posch, Maximilian G., Lehmann, Jeanette, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480294/
https://www.ncbi.nlm.nih.gov/pubmed/37532923
http://dx.doi.org/10.1007/s13318-023-00847-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480294/
https://www.ncbi.nlm.nih.gov/pubmed/37532923
http://dx.doi.org/10.1007/s13318-023-00847-3

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