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IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy

Th9 cells are powerful effector T cells for cancer immunotherapy. However, the underlying antitumor mechanism of Th9 cells still needs to be further elucidated. Here, we show that Th9 cells express high levels of not only IL-9, but also IL-24. We found that knockout of Il24 gene in Th9 cells promote...

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Detalles Bibliográficos
Autores principales: Chen, Jintong, Zhang, Yunwei, Zhang, Hua, Zhang, Mingyue, Dong, He, Qin, Tianxue, Gao, Sujun, Wang, Siqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480301/
https://www.ncbi.nlm.nih.gov/pubmed/37680459
http://dx.doi.org/10.1016/j.isci.2023.107531