Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported. However, determining which components of this cellular heterogeneity serve a diabetes-relevant function remains challenging. Here, we integrate single-cell transcriptome, single-nuclei chromatin accessibility,...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Chen, Gu, Anniya, Zhang, Shanshan, Lu, Leina, Ke, Luxin, Gao, Peidong, Liu, Xiaoxiao, Wang, Yuntong, Hu, Peinan, Plummer, Dylan, MacDonald, Elise, Zhang, Saixian, Xi, Jiajia, Lai, Sisi, Leskov, Konstantin, Yuan, Kyle, Jin, Fulai, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480445/
https://www.ncbi.nlm.nih.gov/pubmed/37669939
http://dx.doi.org/10.1038/s41467-023-41228-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480445/
https://www.ncbi.nlm.nih.gov/pubmed/37669939
http://dx.doi.org/10.1038/s41467-023-41228-3

Ejemplares similares