AhR diminishes the efficacy of chemotherapy via suppressing STING dependent type-I interferon in bladder cancer

The induction of type-I interferons (IFN-Is) is important for the efficacy of chemotherapy. By investigating the role of amino acids in regulation of IFN-I production under chemo-drug treatment in bladder cancer (BC) cells, we find an inherent AhR-dependent negative feedback to restrain STING signal...

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Detalles Bibliográficos
Autores principales: Ma, Zikun, Li, Zhiyong, Mao, Yize, Ye, Jingwei, Liu, Zefu, Wang, Yuzhao, Wei, Chen, Cui, Jun, Liu, Zhuowei, Liang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480448/
https://www.ncbi.nlm.nih.gov/pubmed/37670034
http://dx.doi.org/10.1038/s41467-023-41218-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480448/
https://www.ncbi.nlm.nih.gov/pubmed/37670034
http://dx.doi.org/10.1038/s41467-023-41218-5

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