MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

Nonalcoholic steatohepatitis (NASH) is triggered by hepatocyte death through activation of caspase 6, as a result of decreased adenosine monophosphate (AMP)-activated protein kinase-alpha (AMPKα) activity. Increased hepatocellular death promotes inflammation which drives hepatic fibrosis. We show th...

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Detalles Bibliográficos
Autores principales: Qiu, Bin, Lawan, Ahmed, Xirouchaki, Chrysovalantou E., Yi, Jae-Sung, Robert, Marie, Zhang, Lei, Brown, Wendy, Fernández-Hernando, Carlos, Yang, Xiaoyong, Tiganis, Tony, Bennett, Anton M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480499/
https://www.ncbi.nlm.nih.gov/pubmed/37669951
http://dx.doi.org/10.1038/s41467-023-41145-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480499/
https://www.ncbi.nlm.nih.gov/pubmed/37669951
http://dx.doi.org/10.1038/s41467-023-41145-5

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