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Oxidation of polysorbates – An underestimated degradation pathway?

To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation. In this context, polysorbate 20 and 80 are the most used detergents. Despite their benefits of low toxicity a...

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Detalles Bibliográficos
Autores principales: Weber, Johanna, Buske, Julia, Mäder, Karsten, Garidel, Patrick, Diederichs, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480556/
https://www.ncbi.nlm.nih.gov/pubmed/37680877
http://dx.doi.org/10.1016/j.ijpx.2023.100202