Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer

Most circulating tumor cells (CTC) are detected as single cells, whereas a small proportion of CTCs in multicellular clusters with stemness properties possess 20- to 100-times higher metastatic propensity than the single cells. Here we report that CTC dynamics in both singles and clusters in respons...

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Detalles Bibliográficos
Autores principales: Dashzeveg, Nurmaa K., Jia, Yuzhi, Zhang, Youbin, Gerratana, Lorenzo, Patel, Priyam, Shajahan, Asif, Dandar, Tsogbadrakh, Ramos, Erika K., Almubarak, Hannah F., Adorno-Cruz, Valery, Taftaf, Rokana, Schuster, Emma J., Scholten, David, Sokolowski, Michael T., Reduzzi, Carolina, El-Shennawy, Lamiaa, Hoffmann, Andrew D., Manai, Maroua, Zhang, Qiang, D'Amico, Paolo, Azadi, Parastoo, Colley, Karen J., Platanias, Leonidas C., Shah, Ami N., Gradishar, William J., Cristofanilli, Massimo, Muller, William A., Cobb, Brian A., Liu, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481132/
https://www.ncbi.nlm.nih.gov/pubmed/37272843
http://dx.doi.org/10.1158/2159-8290.CD-22-0644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481132/
https://www.ncbi.nlm.nih.gov/pubmed/37272843
http://dx.doi.org/10.1158/2159-8290.CD-22-0644

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