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SETD1A‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells

BACKGROUND: Histone methyltransferases are crucial regulators in non‐small cell lung cancer (NSCLC) development. This study explored the mechanism of histone methyltransferase SET domain containing 1A (SETD1A)‐mediated H3K4me2 methylation in NSCLC cell ferroptosis and provides novel targets for NSCL...

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Detalles Bibliográficos
Autores principales: Shi, Zhenliang, Zhang, Hao, Shen, Yimeng, Zhang, Sipei, Zhang, Xun, Xu, Yijun, Sun, Daqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481147/
https://www.ncbi.nlm.nih.gov/pubmed/37548102
http://dx.doi.org/10.1111/1759-7714.15037