Assessing seizure liability in vitro with voltage-sensitive dye imaging in mouse hippocampal slices

Non-clinical toxicology is a major cause of drug candidate attrition during development. In particular, drug-induced seizures are the most common finding in central nervous system (CNS) toxicity. Current safety pharmacology tests for assessing CNS functions are often inadequate in detecting seizure-...

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Detalles Bibliográficos
Autores principales: Utsumi, Yuichi, Taketoshi, Makiko, Miwa, Michiko, Tominaga, Yoko, Tominaga, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481167/
https://www.ncbi.nlm.nih.gov/pubmed/37680865
http://dx.doi.org/10.3389/fncel.2023.1217368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481167/
https://www.ncbi.nlm.nih.gov/pubmed/37680865
http://dx.doi.org/10.3389/fncel.2023.1217368

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