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Assessing seizure liability in vitro with voltage-sensitive dye imaging in mouse hippocampal slices
Non-clinical toxicology is a major cause of drug candidate attrition during development. In particular, drug-induced seizures are the most common finding in central nervous system (CNS) toxicity. Current safety pharmacology tests for assessing CNS functions are often inadequate in detecting seizure-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481167/ https://www.ncbi.nlm.nih.gov/pubmed/37680865 http://dx.doi.org/10.3389/fncel.2023.1217368 |