Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease

INTRODUCTION: The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer’s disease (LOAD). METHODS:...

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Detalles Bibliográficos
Autores principales: Castranio, Emilie L., Hasel, Philip, Haure-Mirande, Jean-Vianney, Ramirez Jimenez, Angie V., Hamilton, B. Wade, Kim, Rachel D., Glabe, Charles G., Wang, Minghui, Zhang, Bin, Gandy, Sam, Liddelow, Shane A., Ehrlich, Michelle E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481344/
https://www.ncbi.nlm.nih.gov/pubmed/36448627
http://dx.doi.org/10.1002/alz.12821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481344/
https://www.ncbi.nlm.nih.gov/pubmed/36448627
http://dx.doi.org/10.1002/alz.12821

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