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In Situ Cocrystallization via Spray Drying with Polymer as a Strategy to Prevent Cocrystal Dissociation

[Image: see text] The aim of the present study was to investigate how different polymers affect the dissociation of cocrystals prepared by co-spray-drying active pharmaceutical ingredient (API), coformer, and polymer. Diclofenac acid–l-proline cocrystal (DPCC) was selected in this study as a model c...

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Detalles Bibliográficos
Autores principales: Shao, ShiZhe, Stocker, Michael W., Zarrella, Salvatore, Korter, Timothy M., Singh, Abhishek, Healy, Anne Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481393/
https://www.ncbi.nlm.nih.gov/pubmed/37595572
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00564