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RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome

BACKGROUND: RUNX1 is a transcription factor and a master regulator for the specification of the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis. Mutations and rearrangements on RUNX1 are key drivers of hematological malignancies. In humans, this gene is localized to the ‘Do...

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Detalles Bibliográficos
Autores principales: Rozen, Esteban J., Ozeroff, Christopher D., Allen, Mary Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481493/
https://www.ncbi.nlm.nih.gov/pubmed/37670378
http://dx.doi.org/10.1186/s40246-023-00531-2