Cargando…
RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome
BACKGROUND: RUNX1 is a transcription factor and a master regulator for the specification of the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis. Mutations and rearrangements on RUNX1 are key drivers of hematological malignancies. In humans, this gene is localized to the ‘Do...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481493/ https://www.ncbi.nlm.nih.gov/pubmed/37670378 http://dx.doi.org/10.1186/s40246-023-00531-2 |