Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition

BACKGROUND: Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change and synapse loss. Microglia is the resistant immune cell in brain and retina and has been demonstrated to be highly related with neuron and synapse injury. However, the fun...

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Detalles Bibliográficos
Autores principales: Yao, Ke, Mou, Qianxue, Lou, Xiaotong, Ye, Meng, Zhao, Bowen, Hu, Yuanyuan, Luo, Jing, Zhang, Hong, Li, Xing, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481494/
https://www.ncbi.nlm.nih.gov/pubmed/37670386
http://dx.doi.org/10.1186/s12974-023-02886-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481494/
https://www.ncbi.nlm.nih.gov/pubmed/37670386
http://dx.doi.org/10.1186/s12974-023-02886-8

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