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Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection, most diffuse high-grade gliomas are treated with adjuvant chemotherapy and radiation. Recurrent/progressive diffuse gliomas may show genetic...
Autores principales: | Wood, Matthew D., Beadling, Carol, Neff, Tanaya, Moore, Steve, Harrington, Christina A., Baird, Lissa, Corless, Christopher |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481558/ https://www.ncbi.nlm.nih.gov/pubmed/37670377 http://dx.doi.org/10.1186/s40478-023-01644-4 |
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