Biodistribution of recombinant factor IX, extended half-life recombinant factor IX Fc fusion protein, and glycoPEGylated recombinant factor IX in hemophilia B mice

Extended half-life recombinant FIX (rFIX) molecules have been generated to reduce the dosing burden and increase the protection of patients with hemophilia B. Clinical pharmacology studies with recombinant factor IX Fc fusion protein (rFIXFc) report a similar initial peak plasma recovery to that of...

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Detalles Bibliográficos
Autores principales: van der Flier, Arjan, Hong, Vu, Liu, Zhan, Piepenhagen, Peter, Ulinski, Gregory, Dumont, Jennifer A., Orcutt, Kelly D., Goel, Apollina, Peters, Robert, Salas, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481914/
https://www.ncbi.nlm.nih.gov/pubmed/37577860
http://dx.doi.org/10.1097/MBC.0000000000001230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481914/
https://www.ncbi.nlm.nih.gov/pubmed/37577860
http://dx.doi.org/10.1097/MBC.0000000000001230

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