Discovery of new Schistosoma mansoni aspartyl protease inhibitors by structure-based virtual screening

BACKGROUND: Schistosomiasis is a neglected tropical disease caused by trematodes of the genus Schistosoma, with a limited treatment, mainly based on the use of praziquantel (PZQ). Currently, several aspartic proteases genes have already been identified within the genome of Schistosoma species. At le...

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Detalles Bibliográficos
Autores principales: Gomes, Bárbara Figueira, Senger, Mario Roberto, Moreira-Filho, José Teófilo, de Vasconcellos, Fabio Jorge, Dantas, Rafael Ferreira, Owens, Raymond, Andrade, Carolina Horta, Neves, Bruno Junior, Silva-Junior, Floriano Paes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481938/
https://www.ncbi.nlm.nih.gov/pubmed/37672425
http://dx.doi.org/10.1590/0074-02760230031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481938/
https://www.ncbi.nlm.nih.gov/pubmed/37672425
http://dx.doi.org/10.1590/0074-02760230031

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