A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4

Hereditary spastic paraplegia (HSP) is a group of degenerative neurological disorders. We identified a variant in human kinesin light chain 4 (KLC4) that is suspected to be associated with autosomal-dominant HSP. How this and other variants relate to pathologies is unknown. We created a humanized Ca...

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Detalles Bibliográficos
Autores principales: Gümüşderelioğlu, Selin, Resch, Lauren, Brock, Trisha, Luxton, G. W. Gant, Cope, Heidi, Tan, Queenie K.-G., Hopkins, Christopher, Starr, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481945/
https://www.ncbi.nlm.nih.gov/pubmed/37565267
http://dx.doi.org/10.1242/dmm.050076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481945/
https://www.ncbi.nlm.nih.gov/pubmed/37565267
http://dx.doi.org/10.1242/dmm.050076

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