Probing the substrate binding modes and catalytic mechanisms of BLEG-1, a promiscuous B3 metallo-β-lactamase with glyoxalase II properties

BLEG-1 from Bacillus lehensis G1 is an evolutionary divergent B3 metallo-β-lactamase (MBL) that exhibited both β-lactamase and glyoxalase II (GLXII) activities. Sequence, phylogeny, biochemical and structural relatedness of BLEG-1 to B3 MBL and GLXII suggested BLEG-1 might be an intermediate in the...

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Detalles Bibliográficos
Autores principales: Au, Shaw Xian, Mohd Padzil, Azyyati, Muhd Noor, Noor Dina, Matsumura, Hiroyoshi, Raja Abdul Rahman, Raja Noor Zaliha, Normi, Yahaya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482274/
https://www.ncbi.nlm.nih.gov/pubmed/37672512
http://dx.doi.org/10.1371/journal.pone.0291012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482274/
https://www.ncbi.nlm.nih.gov/pubmed/37672512
http://dx.doi.org/10.1371/journal.pone.0291012

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