Cargando…

Probing the substrate binding modes and catalytic mechanisms of BLEG-1, a promiscuous B3 metallo-β-lactamase with glyoxalase II properties

BLEG-1 from Bacillus lehensis G1 is an evolutionary divergent B3 metallo-β-lactamase (MBL) that exhibited both β-lactamase and glyoxalase II (GLXII) activities. Sequence, phylogeny, biochemical and structural relatedness of BLEG-1 to B3 MBL and GLXII suggested BLEG-1 might be an intermediate in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Au, Shaw Xian, Mohd Padzil, Azyyati, Muhd Noor, Noor Dina, Matsumura, Hiroyoshi, Raja Abdul Rahman, Raja Noor Zaliha, Normi, Yahaya M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482274/ https://www.ncbi.nlm.nih.gov/pubmed/37672512 http://dx.doi.org/10.1371/journal.pone.0291012

Ejemplares similares

Dual Activity BLEG-1 from Bacillus lehensis G1 Revealed Structural Resemblance to B3 Metallo-β-Lactamase and Glyoxalase II: An Insight into Its Enzyme Promiscuity and Evolutionary Divergence
por: Au, Shaw Xian, et al.
Publicado: (2021)

Procedure of the overexpression, purification and crystallization of BLEG-1, a bifunctional and evolutionary divergent B3 metallo-β-lactamase, for structure-function studies
por: Au, Shaw Xian, et al.
Publicado: (2022)

Design and Characterisation of Inhibitory Peptides against Bleg1_2478, an Evolutionary Divergent B3 Metallo-β-lactamase
por: Selvaraju, Gayathri, et al.
Publicado: (2020)

Lid opening and conformational stability of T1 Lipase is mediated by increasing chain length polar solvents
por: Maiangwa, Jonathan, et al.
Publicado: (2017)

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism
por: Palacios, Antonela R., et al.
Publicado: (2020)

A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family
por: Perez-Garcia, Pablo, et al.
Publicado: (2021)

Effects of Lid 1 Mutagenesis on Lid Displacement, Catalytic Performances and Thermostability of Cold-active Pseudomonas AMS8 Lipase in Toluene
por: Yaacob, Norhayati, et al.
Publicado: (2019)

Analysis of Comparative Sequence and Genomic Data to Verify Phylogenetic Relationship and Explore a New Subfamily of Bacterial Lipases
por: Masomian, Malihe, et al.
Publicado: (2016)

Geobacillus zalihae sp. nov., a thermophilic lipolytic bacterium isolated from palm oil mill effluent in Malaysia
por: Rahman, Raja Noor Zaliha Raja Abd, et al.
Publicado: (2007)

Role of α-Helical Structure in Organic Solvent-Activated Homodimer of Elastase Strain K
por: Rahman, Raja Noor Zaliha Raja Abd., et al.
Publicado: (2011)

A Newly Isolated Thermostable Lipase from Bacillus sp.
por: Shariff, Fairolniza Mohd, et al.
Publicado: (2011)

Enzymatic Properties and Mutational Studies of Chalcone Synthase from Physcomitrella patens
por: Rahman, Raja Noor Zaliha Raja Abdul, et al.
Publicado: (2012)

3D Structure Elucidation of Thermostable L2 Lipase from Thermophilic Bacillus sp. L2
por: Abd. Rahman, Raja Noor Zaliha Raja, et al.
Publicado: (2012)

The Mechanisms of Catalysis by Metallo β-Lactamases
por: Page, Michael I., et al.
Publicado: (2008)

Molecular Cloning and Functional Expression of a Δ9- Fatty Acid Desaturase from an Antarctic Pseudomonas sp. A3
por: Garba, Lawal, et al.
Publicado: (2016)

Single Residue Substitution at N-Terminal Affects Temperature Stability and Activity of L2 Lipase
por: Bukhari, Noramirah, et al.
Publicado: (2020)

High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan
por: Ain, Noor Ul, et al.
Publicado: (2018)

Expression and characterization of thermostable glycogen branching enzyme from Geobacillus mahadia Geo-05
por: Mohtar, Nur Syazwani, et al.
Publicado: (2016)

Characterisation of bacteria isolated from the stingless bee, Heterotrigona itama, honey, bee bread and propolis
por: Ngalimat, Mohamad Syazwan, et al.
Publicado: (2019)

New metallo β-lactamase NDM-1
por: Raghunath, D.
Publicado: (2010)

Metallo-β-Lactamases and Aptamer-Based Inhibition
por: Schlesinger, Sara R., et al.
Publicado: (2011)

Use of ferrous iron by metallo-β-lactamases
por: Cahill, Samuel T., et al.
Publicado: (2016)

Profiling interactions of vaborbactam with metallo-β-lactamases
por: Langley, Gareth W., et al.
Publicado: (2019)

Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
por: Palica, Katarzyna, et al.
Publicado: (2022)

Comparison of Epidemiological and Antibiotic Susceptibility Pattern of Metallo-Beta-Lactamase-Positive and Metallo-Beta-Lactamase-Negative Strains of Pseudomonas Aeruginosa
por: Ranjan, Shikha, et al.
Publicado: (2014)

Optimization of physical factors affecting the production of thermo-stable organic solvent-tolerant protease from a newly isolated halo tolerant Bacillus subtilis strain Rand
por: Abusham, Randa A, et al.
Publicado: (2009)

The Metallo-β-Lactamase/β-CASP Domain of Artemis Constitutes the Catalytic Core for V(D)J Recombination
por: Poinsignon, Catherine, et al.
Publicado: (2004)

Expression of an Organic Solvent Stable Lipase from Staphylococcus epidermidis AT2
por: Rahman, Raja Noor Zaliha Raja Abd., et al.
Publicado: (2010)

Molecular Cloning and Optimization for High Level Expression of Cold-Adapted Serine Protease from Antarctic Yeast Glaciozyma antarctica PI12
por: Alias, Norsyuhada, et al.
Publicado: (2014)

Expression and Characterization of Geobacillus stearothermophilus SR74 Recombinant α-Amylase in Pichia pastoris
por: Gandhi, Sivasangkary, et al.
Publicado: (2015)

Improving the Efficiency of New Automatic Dishwashing Detergent Formulation by Addition of Thermostable Lipase, Protease and Amylase
por: Naganthran, Ashwini, et al.
Publicado: (2017)

Microbial Biodegradation of Paraffin Wax in Malaysian Crude Oil Mediated by Degradative Enzymes
por: Adlan, Nur Aina, et al.
Publicado: (2020)

The Role of Surface Exposed Lysine in Conformational Stability and Functional Properties of Lipase from Staphylococcus Family
por: Ahmad, Nurul Nadirah, et al.
Publicado: (2020)

A modeling study by response surface methodology and artificial neural network on culture parameters optimization for thermostable lipase production from a newly isolated thermophilic Geobacillus sp. strain ARM
por: Ebrahimpour, Afshin, et al.
Publicado: (2008)

Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
por: Rezaee, Malahat, et al.
Publicado: (2014)

Directed Evolution of Recombinant C-Terminal Truncated Staphylococcus epidermidis Lipase AT2 for the Enhancement of Thermostability
por: Veno, Jiivittha, et al.
Publicado: (2017)

Insight into Improved Thermostability of Cold-Adapted Staphylococcal Lipase by Glycine to Cysteine Mutation
por: Veno, Jiivittha, et al.
Publicado: (2019)

VIM-1 Metallo-β-lactamase in Acinetobacter baumannii
por: Tsakris, Athanassios, et al.
Publicado: (2006)

New Delhi Metallo-β-Lactamase, Ontario, Canada
por: Tijet, Nathalie, et al.
Publicado: (2011)

Emergence of New Delhi Metallo-β-Lactamase, Austria
por: Zarfel, Gernot, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ihkfouspaqprbk8csedc6ba845