Mathematical modeling indicates that regulatory inhibition of CD8(+) T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

Immunotherapeutic cytokines can activate immune cells against cancers and chronic infections. N-803 is an IL-15 superagonist that expands CD8(+) T cells and increases their cytotoxicity. N-803 also temporarily reduced viral load in a limited subset of non-human primates infected with simian immunode...

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Detalles Bibliográficos
Autores principales: Cody, Jonathan W., Ellis-Connell, Amy L., O’Connor, Shelby L., Pienaar, Elsje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482305/
https://www.ncbi.nlm.nih.gov/pubmed/37616311
http://dx.doi.org/10.1371/journal.pcbi.1011425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482305/
https://www.ncbi.nlm.nih.gov/pubmed/37616311
http://dx.doi.org/10.1371/journal.pcbi.1011425

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