Loss of attachment promotes proline accumulation and excretion in cancer cells

Previous studies have revealed a role for proline metabolism in supporting cancer development and metastasis. In this study, we show that many cancer cells respond to loss of attachment by accumulating and secreting proline. Detached cells display reduced proliferation accompanied by a general decre...

Descripción completa

Detalles Bibliográficos
Autores principales: Pilley, Steven E., Hennequart, Marc, Vandekeere, Anke, Blagih, Julianna, Legrave, Nathalie M., Fendt, Sarah-Maria, Vousden, Karen H., Labuschagne, Christiaan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482343/
https://www.ncbi.nlm.nih.gov/pubmed/37672588
http://dx.doi.org/10.1126/sciadv.adh2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482343/
https://www.ncbi.nlm.nih.gov/pubmed/37672588
http://dx.doi.org/10.1126/sciadv.adh2023

Ejemplares similares