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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging
Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that captures heterogeneous spatial protein expression patterns at subcellular resolution. Here we report the extension of IMC to low-abundance markers through incorporation of the DNA-based signal amplification by e...
Autores principales: | Hosogane, Tsuyoshi, Casanova, Ruben, Bodenmiller, Bernd |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482679/ https://www.ncbi.nlm.nih.gov/pubmed/37653118 http://dx.doi.org/10.1038/s41592-023-01976-y |
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