Efficient high-precision homology-directed repair-dependent genome editing by HDRobust

Homology-directed repair (HDR), a method for repair of DNA double-stranded breaks can be leveraged for the precise introduction of mutations supplied by synthetic DNA donors, but remains limited by low efficiency and off-target effects. In this study, we report HDRobust, a high-precision method that...

Descripción completa

Detalles Bibliográficos
Autores principales: Riesenberg, Stephan, Kanis, Philipp, Macak, Dominik, Wollny, Damian, Düsterhöft, Dorothee, Kowalewski, Johannes, Helmbrecht, Nelly, Maricic, Tomislav, Pääbo, Svante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482697/
https://www.ncbi.nlm.nih.gov/pubmed/37474806
http://dx.doi.org/10.1038/s41592-023-01949-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482697/
https://www.ncbi.nlm.nih.gov/pubmed/37474806
http://dx.doi.org/10.1038/s41592-023-01949-1

Ejemplares similares