Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic lysosomal lipid accumulation. Reduced LAL activ...

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Detalles Bibliográficos
Autores principales: Bradić, Ivan, Liesinger, Laura, Kuentzel, Katharina B., Vujić, Nemanja, Trauner, Michael, Birner-Gruenberger, Ruth, Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Metabolic Liver Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482749/
https://www.ncbi.nlm.nih.gov/pubmed/37595802
http://dx.doi.org/10.1016/j.jlr.2023.100427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482749/
https://www.ncbi.nlm.nih.gov/pubmed/37595802
http://dx.doi.org/10.1016/j.jlr.2023.100427

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