Cargando…

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic lysosomal lipid accumulation. Reduced LAL activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bradić, Ivan, Liesinger, Laura, Kuentzel, Katharina B., Vujić, Nemanja, Trauner, Michael, Birner-Gruenberger, Ruth, Kratky, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article Collection: Metabolic Liver Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482749/ https://www.ncbi.nlm.nih.gov/pubmed/37595802 http://dx.doi.org/10.1016/j.jlr.2023.100427

Ejemplares similares

Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
por: Bradić, Ivan, et al.
Publicado: (2022)

Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth
por: Kuentzel, Katharina B., et al.
Publicado: (2021)

Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases
por: Schittmayer, Matthias, et al.
Publicado: (2020)

ATG7 is dispensable for LC3–PE conjugation in thioglycolate-elicited mouse peritoneal macrophages
por: Vujić, Nemanja, et al.
Publicado: (2021)

Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase
por: Sachdev, Vinay, et al.
Publicado: (2021)

Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice
por: Radović, Branislav, et al.
Publicado: (2016)

Ultra‐high‐field magnetic resonance spectroscopy in non‐alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non‐alcoholic steatohepatitis and advanced fibrosis
por: Traussnigg, Stefan, et al.
Publicado: (2017)

Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH
por: Bruschi, Francesca V., et al.
Publicado: (2020)

Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice
por: Goeritzer, Madeleine, et al.
Publicado: (2023)

Serum coding and non‐coding RNAs as biomarkers of NAFLD and fibrosis severity
por: Di Mauro, Stefania, et al.
Publicado: (2019)

Sebelipase alfa for lysosomal acid lipase deficiency: 5‐year treatment experience from a phase 2 open‐label extension study
por: Malinová, Vĕra, et al.
Publicado: (2020)

Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis(☆)
por: Korbelius, Melanie, et al.
Publicado: (2022)

Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients
por: Mueller, Michaela, et al.
Publicado: (2017)

Prevalence estimation of significant fibrosis because of NASH in Spain combining transient elastography and histology
por: Calleja, José L., et al.
Publicado: (2022)

Absence of Bsep/Abcb11 attenuates MCD diet‐induced hepatic steatosis but aggravates inflammation in mice
por: Fuchs, Claudia D., et al.
Publicado: (2020)

Multiparametric magnetic resonance imaging for the assessment of non‐alcoholic fatty liver disease severity
por: Pavlides, Michael, et al.
Publicado: (2017)

Prescription of statins in suspected non‐alcoholic fatty liver disease and high cardiovascular risk, a population‐based study
por: van den Berg, Eline H., et al.
Publicado: (2019)

Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis
por: Allende, Daniela S, et al.
Publicado: (2021)

Diagnostic accuracy of fibrosis tests in children with non‐alcoholic fatty liver disease: A systematic review
por: Draijer, Laura G., et al.
Publicado: (2021)

Magnetic Resonance Elastography Predicts Advanced Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Study
por: Loomba, Rohit, et al.
Publicado: (2014)

Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real‐world data analysis
por: Colosimo, Santo, et al.
Publicado: (2021)

Impact of osteopontin on the development of non‐alcoholic liver disease and related hepatocellular carcinoma
por: Nardo, Alexander D., et al.
Publicado: (2020)

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood
por: Decaris, Martin L., et al.
Publicado: (2016)

Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo
por: Goeritzer, Madeleine, et al.
Publicado: (2022)

Repeated measurements of non‐invasive fibrosis tests to monitor the progression of non‐alcoholic fatty liver disease: A long‐term follow‐up study
por: Balkhed, Wile, et al.
Publicado: (2022)

Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration
por: Bianco, Valentina, et al.
Publicado: (2023)

Alpha‐fetoprotein‐adjusted‐to‐HCC‐size criteria are associated with favourable survival after liver transplantation for hepatocellular carcinoma
por: Meischl, Tobias, et al.
Publicado: (2021)

Tissue-Specific Landscape of Metabolic Dysregulation during Ageing
por: Zhang, Fangrong, et al.
Publicado: (2021)

Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice
por: Kuentzel, Katharina B., et al.
Publicado: (2022)

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
por: McPherson, Stuart, et al.
Publicado: (2017)

Endothelial lipase increases antioxidative capacity of high-density lipoprotein
por: Schilcher, Irene, et al.
Publicado: (2019)

Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descent
por: De Silva, Sampath, et al.
Publicado: (2018)

Comparison of various strategies to define the optimal target population for liver fibrosis screening: A population‐based cohort study
por: Åberg, Fredrik, et al.
Publicado: (2022)

Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism
por: Zhou, Qishun, et al.
Publicado: (2021)

Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice
por: Zhou, Qishun, et al.
Publicado: (2022)

A Phase 1/2, Dose-Escalation Trial of Deferasirox for the Treatment of Iron Overload in HFE-Related Hereditary Hemochromatosis
por: Phatak, Pradyumna, et al.
Publicado: (2010)

Apolipoprotein CIII Overexpressing Mice Are Predisposed to Diet-Induced Hepatic Steatosis and Hepatic Insulin Resistance
por: Lee, Hui-Young, et al.
Publicado: (2011)

Dissociation Between APOC3 Variants, Hepatic Triglyceride Content and Insulin Resistance
por: Kozlitina, Julia, et al.
Publicado: (2011)

Effect of Colesevelam on Liver Fat Quantified by Magnetic Resonance in Nonalcoholic Steatohepatitis: A Randomized Controlled Trial
por: Le, Thuy-Anh, et al.
Publicado: (2012)

Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats
por: Kumashiro, Naoki, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tvccp1o6snh6ebie5dqsm0r55c