Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

Preventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation has been found to facilitate the formation of pathogenic tau conformations and fibrillar aggregates, although many aspects of the conformational trans...

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Detalles Bibliográficos
Autores principales: Huang, Yongqi, Wen, Jitao, Ramirez, Lisa-Marie, Gümüşdil, Eymen, Pokhrel, Pravin, Man, Viet H., Ye, Haiqiong, Han, Yue, Liu, Yunfei, Li, Ping, Su, Zhengding, Wang, Junmei, Mao, Hanbin, Zweckstetter, Markus, Perrett, Sarah, Wu, Si, Gao, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482834/
https://www.ncbi.nlm.nih.gov/pubmed/37673952
http://dx.doi.org/10.1038/s41467-023-41241-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482834/
https://www.ncbi.nlm.nih.gov/pubmed/37673952
http://dx.doi.org/10.1038/s41467-023-41241-6

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