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Tracing the birth of structural domains from loops during protein evolution

The structures and functions of proteins are embedded into the loop scaffolds of structural domains. Their origin and evolution remain mysterious. Here, we use a novel graph-theoretical approach to describe how modular and non-modular loop prototypes combine to form folded structures in protein doma...

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Detalles Bibliográficos
Autores principales: Aziz, M. Fayez, Mughal, Fizza, Caetano-Anollés, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482863/
https://www.ncbi.nlm.nih.gov/pubmed/37673948
http://dx.doi.org/10.1038/s41598-023-41556-w