Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. Here we show levels of serum hyodeoxycholic acid (HDCA) decrease in both NAFLD patients and mice, as well as in liver and...

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Detalles Bibliográficos
Autores principales: Zhong, Jing, He, Xiaofang, Gao, Xinxin, Liu, Qiaohong, Zhao, Yu, Hong, Ying, Zhu, Weize, Yan, Juan, Li, Yifan, Li, Yan, Zheng, Ningning, Bao, Yiyang, Wang, Hao, Ma, Junli, Huang, Wenjin, Liu, Zekun, Lyu, Yuanzhi, Ke, Xisong, Jia, Wei, Xie, Cen, Hu, Yiyang, Sheng, Lili, Li, Houkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482907/
https://www.ncbi.nlm.nih.gov/pubmed/37673856
http://dx.doi.org/10.1038/s41467-023-41061-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482907/
https://www.ncbi.nlm.nih.gov/pubmed/37673856
http://dx.doi.org/10.1038/s41467-023-41061-8

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