Cargando…

Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. Here we show levels of serum hyodeoxycholic acid (HDCA) decrease in both NAFLD patients and mice, as well as in liver and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Jing, He, Xiaofang, Gao, Xinxin, Liu, Qiaohong, Zhao, Yu, Hong, Ying, Zhu, Weize, Yan, Juan, Li, Yifan, Li, Yan, Zheng, Ningning, Bao, Yiyang, Wang, Hao, Ma, Junli, Huang, Wenjin, Liu, Zekun, Lyu, Yuanzhi, Ke, Xisong, Jia, Wei, Xie, Cen, Hu, Yiyang, Sheng, Lili, Li, Houkai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482907/ https://www.ncbi.nlm.nih.gov/pubmed/37673856 http://dx.doi.org/10.1038/s41467-023-41061-8

Ejemplares similares

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy
por: Ma, Junli, et al.
Publicado: (2017)

Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice
por: Hong, Ying, et al.
Publicado: (2021)

Microbial and Transcriptomic Profiling Reveals Diet-Related Alterations of Metabolism in Metabolic Disordered Mice
por: Zhu, Weize, et al.
Publicado: (2022)

Hyodeoxycholic acid protects the neurovascular unit against oxygen-glucose deprivation and reoxygenation-induced injury in vitro
por: Li, Chang-Xiang, et al.
Publicado: (2019)

Fecal Hyodeoxycholic Acid Is Correlated With Tylosin-Induced Microbiome Changes in Growing Pigs
por: Trudeau, Michaela P., et al.
Publicado: (2018)

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro
por: Kehlenbach, Ralph H., et al.
Publicado: (1998)

Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives
por: Sabbatini, Paola, et al.
Publicado: (2013)

The Microbial and Metabolic Signatures of Patients with Stable Coronary Artery Disease
por: Zhong, Jing, et al.
Publicado: (2022)

Synthesis of Five Known Brassinosteroid Analogs from Hyodeoxycholic Acid and Their Activities as Plant-Growth Regulators
por: Duran, María Isabel, et al.
Publicado: (2017)

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
por: He, Xuyun, et al.
Publicado: (2016)

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists
por: De Marino, Simona, et al.
Publicado: (2017)

A Novel Drug Delivery System: Hyodeoxycholic Acid-Modified Metformin Liposomes for Type 2 Diabetes Treatment
por: Hu, Minghao, et al.
Publicado: (2023)

The Role of Gut Microbiota in Atherosclerosis and Hypertension
por: Ma, Junli, et al.
Publicado: (2018)

Synthesis of 2-Deoxybrassinosteroids Analogs with 24-nor, 22(S)-23-Dihydroxy-Type Side Chains from Hyodeoxycholic Acid
por: Carvajal, Rodrigo, et al.
Publicado: (2018)

Alginate Alleviates Dextran Sulfate Sodium-Induced Colitis by Promoting Bifidobacterium animalis and Intestinal Hyodeoxycholic Acid Synthesis in Mice
por: Pi, Yu, et al.
Publicado: (2022)

Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials
por: Sue, Kenneth, et al.
Publicado: (2023)

QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice
por: Zhang, Binbin, et al.
Publicado: (2021)

New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases
por: Li, Xiaojing, et al.
Publicado: (2023)

Eye Movements During RAN as an Operationalization of the RAN-Reading “Microcosm”
por: Peters, Jessica Lee, et al.
Publicado: (2020)

Similar Connotation in Chronic Hepatitis B and Nonalcoholic Fatty Liver Patients with Dampness-Heat Syndrome
por: Dai, Jianye, et al.
Publicado: (2013)

Divergent impacts on the gut microbiome and host metabolism induced by traditional Chinese Medicine with Cold or Hot properties in mice
por: Li, Bingbing, et al.
Publicado: (2022)

Update on Pparγ and Nonalcoholic Fatty Liver Disease
por: Ables, Gene P.
Publicado: (2012)

An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid
por: Ma, Chongyang, et al.
Publicado: (2020)

TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis
por: Zhang, Yanmei, et al.
Publicado: (2021)

Ran kan kan /
por: Puente, Tito, 1923-2000
Publicado: (2008)

SR proteins: To shuttle or not to shuttle, that is the question
por: Hammarskjold, Marie-Louise, et al.
Publicado: (2017)

Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway
por: Yang, Jiayao, et al.
Publicado: (2020)

Role of Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease
por: Chen, Changxi, et al.
Publicado: (2022)

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import
Publicado: (1996)

Integrated Metagenomic and Metabolomic Analyses of the Effect of Astragalus Polysaccharides on Alleviating High-Fat Diet–Induced Metabolic Disorders
por: Hong, Ying, et al.
Publicado: (2020)

Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents
por: Fan, Tiantang, et al.
Publicado: (2022)

What makes Ran run?
por: Wells, William A.
Publicado: (2002)

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
por: He, Yujiao, et al.
Publicado: (2021)

Intervening TNF-α via PPARγ with Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease
por: Wang, Yun-liang, et al.
Publicado: (2015)

Integrated Metagenomic and Transcriptomic Analyses Reveal the Dietary Dependent Recovery of Host Metabolism From Antibiotic Exposure
por: Li, Bingbing, et al.
Publicado: (2021)

Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway
por: Huang, Ping, et al.
Publicado: (2022)

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1
Publicado: (1996)

Bibliometric and visual analysis of RAN methylation in cardiovascular disease
por: Song, Boce, et al.
Publicado: (2023)

Ran sticks a GEF to chromatin
por: LeBrasseur, Nicole
Publicado: (2003)

Big proteins Ran into import difficulties
por: LeBrasseur, Nicole
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_lt0qmbi5909vki9213gr3s0414