Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy

The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy development. Here, we introduce a light-sensitive optogenetic device for control of the cGAS/STING signaling to conditionally modulate innate immunity, called ‘light-inducible SMOC-like repeats’ (LiSmore). We demons...

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Detalles Bibliográficos
Autores principales: Dou, Yaling, Chen, Rui, Liu, Siyao, Lee, Yi-Tsang, Jing, Ji, Liu, Xiaoxuan, Ke, Yuepeng, Wang, Rui, Zhou, Yubin, Huang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482946/
https://www.ncbi.nlm.nih.gov/pubmed/37673917
http://dx.doi.org/10.1038/s41467-023-41164-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482946/
https://www.ncbi.nlm.nih.gov/pubmed/37673917
http://dx.doi.org/10.1038/s41467-023-41164-2

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