Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation

Phosphorylation of IRF3 is critical to induce type I interferon (IFN-I) production in antiviral innate response. Here we report that lysine methyltransferase SMYD2 inhibits the expressions of IFN-I and proinflammatory cytokines in macrophages upon viral infections. The Smyd2-deficient mice are more...

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Detalles Bibliográficos
Autores principales: Wu, Jiacheng, Hu, Ye, Song, Jiaying, Xu, Jia, Zhang, Qian, Chai, Yangyang, Wang, Xin, Wang, Bingjing, Zhao, Yong, Cao, Xuetao, Xu, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482964/
https://www.ncbi.nlm.nih.gov/pubmed/37673879
http://dx.doi.org/10.1038/s41419-023-06118-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482964/
https://www.ncbi.nlm.nih.gov/pubmed/37673879
http://dx.doi.org/10.1038/s41419-023-06118-y

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