TRiC/CCT chaperonin is required for the folding and inhibitory effect of WDTC1 on adipogenesis

Obesity has become a global pandemic. WDTC1 is a WD40-containing protein that functions as an anti-obesity factor. WDTC1 inhibits adipogenesis by working as an adaptor of the CUL4-DDB1 E3 ligase complex. It remains unclear about how WDTC1 is regulated. Here, we show that the TRiC/CCT functions as a...

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Detalles Bibliográficos
Autores principales: Tang, Wen-Shuai, Cen, Xiang, Yao, Shan-Shan, Yin, Shu-Ting, Weng, Li, Zhao, Tong-Jin, Wang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483223/
https://www.ncbi.nlm.nih.gov/pubmed/37691821
http://dx.doi.org/10.3389/fcell.2023.1225628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483223/
https://www.ncbi.nlm.nih.gov/pubmed/37691821
http://dx.doi.org/10.3389/fcell.2023.1225628

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