Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG

Glioblastoma, the most malignant brain tumor in adults, exhibits characteristic patterns of epigenetic alterations that await elucidation. The DNA methylome of glioblastoma revealed recurrent epigenetic silencing of HTATIP2, which encodes a negative regulator of importin β‐mediated cytoplasmic–nucle...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi Tham, Rajakannu, Premnath, Pham, Minh Diêu Thanh, Weman, Leo, Jucht, Alexander, Buri, Michelle C., Van Dommelen, Kristof, Hegi, Monika E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483604/
https://www.ncbi.nlm.nih.gov/pubmed/37491696
http://dx.doi.org/10.1002/1878-0261.13494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483604/
https://www.ncbi.nlm.nih.gov/pubmed/37491696
http://dx.doi.org/10.1002/1878-0261.13494

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