PP2A‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase inhibitors targeting AKT (AKTi) or the glycolysis master regulator pyruvate dehydrogenase kinase (PDKi) have failed to provide clini...

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Detalles Bibliográficos
Autores principales: Denisova, Oxana V., Merisaari, Joni, Huhtaniemi, Riikka, Qiao, Xi, Yetukuri, Laxman, Jumppanen, Mikael, Kaur, Amanpreet, Pääkkönen, Mirva, von Schantz‐Fant, Сarina, Ohlmeyer, Michael, Wennerberg, Krister, Kauko, Otto, Koch, Raphael, Aittokallio, Tero, Taipale, Mikko, Westermarck, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483611/
https://www.ncbi.nlm.nih.gov/pubmed/37458534
http://dx.doi.org/10.1002/1878-0261.13488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483611/
https://www.ncbi.nlm.nih.gov/pubmed/37458534
http://dx.doi.org/10.1002/1878-0261.13488

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