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A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer’s disease
The amyloid-beta peptide (Aβ) is a driver of Alzheimer’s disease (AD). Aβ monomers can aggregate and form larger soluble (oligomers/protofibrils) and insoluble (fibrils) forms. There is evidence that Aβ protofibrils are the most toxic form, but the reasons are not known. Consistent with a critical r...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483626/ https://www.ncbi.nlm.nih.gov/pubmed/37639602 http://dx.doi.org/10.1073/pnas.2309389120 |