Cargando…

A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer’s disease

The amyloid-beta peptide (Aβ) is a driver of Alzheimer’s disease (AD). Aβ monomers can aggregate and form larger soluble (oligomers/protofibrils) and insoluble (fibrils) forms. There is evidence that Aβ protofibrils are the most toxic form, but the reasons are not known. Consistent with a critical r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zu-Lin, Singh, Pradeep K., Calvano, Marissa, Norris, Erin H., Strickland, Sidney
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483626/ https://www.ncbi.nlm.nih.gov/pubmed/37639602 http://dx.doi.org/10.1073/pnas.2309389120

Ejemplares similares

An antibody against HK blocks Alzheimer’s disease peptide β-amyloid−induced bradykinin release in human plasma
por: Chen, Zu-Lin, et al.
Publicado: (2019)

Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
por: Miller, Alyssa, et al.
Publicado: (2023)

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification
por: Kokubo, Hideko, et al.
Publicado: (2009)

Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease
por: Ono, Kenjiro, et al.
Publicado: (2020)

The contact activation system and vascular factors as alternative targets for Alzheimer's disease therapy
por: Singh, Pradeep K., et al.
Publicado: (2021)

Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo
por: Chen, Zu-Lin, et al.
Publicado: (2022)

Amyloid-β Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic
por: Dubnovitsky, Anatoly, et al.
Publicado: (2013)

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease
por: Lannfelt, Lars, et al.
Publicado: (2014)

Correction: Amyloid-β Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic
por: Dubnovitsky, Anatoly, et al.
Publicado: (2013)

Amyloid Oligomers and Protofibrils, but Not Filaments, Self-Replicate from Native Lysozyme
por: Mulaj, Mentor, et al.
Publicado: (2014)

Atomic resolution dynamics on the surface of amyloid β protofibrils probed by solution NMR
por: Fawzi, Nicolas L., et al.
Publicado: (2011)

Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils
por: Groenning, Minna, et al.
Publicado: (2015)

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation
por: Hasecke, Filip, et al.
Publicado: (2020)

Mechanisms of U87 Astrocytoma Cell Uptake and Trafficking of Monomeric versus Protofibril Alzheimer’s Disease Amyloid-β Proteins
por: Li, Yali, et al.
Publicado: (2014)

Conformation‐specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen
por: Bonito‐Oliva, Alessandra, et al.
Publicado: (2019)

Distinct Annular Oligomers Captured along the Assembly and Disassembly Pathways of Transthyretin Amyloid Protofibrils
por: Pires, Ricardo H., et al.
Publicado: (2012)

Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
por: Chen, Zu-Lin, et al.
Publicado: (2022)

Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease
por: Kamali-Moghaddam, Masood, et al.
Publicado: (2010)

Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
por: Martins, Ivo Cristiano, et al.
Publicado: (2008)

Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease
por: Berk-Rauch, Hanna E., et al.
Publicado: (2023)

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
por: Wang, Hao, et al.
Publicado: (2021)

A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment
por: Yamamoto-Imoto, Hitomi, et al.
Publicado: (2018)

Partial Destabilization of Amyloid-β Protofibril by Methionine Photo-Oxidation: A Molecular Dynamic Simulation Study
por: Maghsoodi, Fahimeh, et al.
Publicado: (2023)

Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers
por: Dufort-Gervais, Julien, et al.
Publicado: (2020)

Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
por: Cadete Martini, Alessandra, et al.
Publicado: (2019)

Dynamics of protofibril elongation and association involved in Aβ42 peptide aggregation in Alzheimer’s disease
por: Ghosh, Preetam, et al.
Publicado: (2010)

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures
por: Nikitidou, Elisabeth, et al.
Publicado: (2017)

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes
por: Bortoletto, Angelina S., et al.
Publicado: (2022)

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers
por: Kedia, Niraja, et al.
Publicado: (2019)

CELLULOSE CONTAMINATION: A POSSIBLE SOURCE OF ERROR IN THE INTERPRETATION OF PREVIOUS EXPERIMENTAL EVIDENCE FOR THE α-KERATIN PROTOFIBRIL
por: Millward, G. R.
Publicado: (1969)

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease
por: Zhang, Huiqin, et al.
Publicado: (2021)

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
por: Sardar Sinha, Maitrayee, et al.
Publicado: (2018)

Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core
por: Leonard, Cass, et al.
Publicado: (2021)

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity
por: Yao, Yao, et al.
Publicado: (2014)

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
por: Guzmán-Vélez, Edmarie, et al.
Publicado: (2022)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ(42) Protofibrils in Alzheimer’s Disease
por: Söllvander, Sofia, et al.
Publicado: (2015)

Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer’s Disease
por: Sharari, Sanaa, et al.
Publicado: (2023)

Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease
por: Singh, Prabhakar, et al.
Publicado: (2009)

Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
por: Takeishi, Naoki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p59u3h92asgevo9tnnfadjolls