Human 2′-Deoxynucleoside 5′-Phosphate N-Hydrolase 1: Mechanism of 2′-Deoxyuridine 5′-Monophosphate Hydrolysis

[Image: see text] The enzyme 2′-deoxynucleoside 5′-phosphate N-hydrolase 1 (DNPH1) catalyzes the N-ribosidic bond cleavage of 5-hydroxymethyl-2′-deoxyuridine 5′-monophosphate to generate 2-deoxyribose 5-phosphate and 5-hydroxymethyluracil. DNPH1 accepts other 2′-deoxynucleoside 5′-monophosphates as...

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Detalles Bibliográficos
Autores principales: Devi, Suneeta, Carberry, Anna E., Zickuhr, Greice M., Dickson, Alison L., Harrison, David J., da Silva, Rafael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483697/
https://www.ncbi.nlm.nih.gov/pubmed/37582341
http://dx.doi.org/10.1021/acs.biochem.3c00369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483697/
https://www.ncbi.nlm.nih.gov/pubmed/37582341
http://dx.doi.org/10.1021/acs.biochem.3c00369

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