Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

BACKGROUND: Osteoarthritis (OA), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ECM) and the apoptosis of chondrocytes. Ajugol, a extract derived from the herb Rehmannia glutinosa, has not yet been investigated for its potential...

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Detalles Bibliográficos
Autores principales: Wu, Jingtao, Yu, Heng, Jin, Yangcan, Wang, Jingquan, Zhou, Liwen, Cheng, Teng, Zhang, Zhao, Lin, Binghao, Miao, Jiansen, Lin, Zhongke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483732/
https://www.ncbi.nlm.nih.gov/pubmed/37679844
http://dx.doi.org/10.1186/s13020-023-00824-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483732/
https://www.ncbi.nlm.nih.gov/pubmed/37679844
http://dx.doi.org/10.1186/s13020-023-00824-7

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