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Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

BACKGROUND: Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a comprehensive investigation in lung adenocarcinoma (LUAD). METHODS: Multiplex fluorescence‐based immunohistochemistry was conducted to assess Siglec-15 expressio...

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Detalles Bibliográficos
Autores principales: Li, Baihui, Guo, Yan, Yi, Yeran, Huang, Ziqi, Ren, Yulin, Wang, Hao, Yang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483852/
https://www.ncbi.nlm.nih.gov/pubmed/37674198
http://dx.doi.org/10.1186/s12967-023-04489-6