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Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison

PURPOSE: To investigate the differences in peripapillary vessel density (VD) between compressive optic neuropathy (CON) and normal-tension glaucoma (NTG). METHODS: We compared patients with chronic CON and NTG, particularly after strictly controlling the mean extent of macular damage by the area of...

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Autores principales: Lee, Eun Jung, Han, Jong Chul, Kee, Changwon, Park, Kyung-Ah, Kong, Doo-Sik, Hong, Sang Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484018/
https://www.ncbi.nlm.nih.gov/pubmed/37672287
http://dx.doi.org/10.1167/iovs.64.12.10
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author Lee, Eun Jung
Han, Jong Chul
Kee, Changwon
Park, Kyung-Ah
Kong, Doo-Sik
Hong, Sang Duk
author_facet Lee, Eun Jung
Han, Jong Chul
Kee, Changwon
Park, Kyung-Ah
Kong, Doo-Sik
Hong, Sang Duk
author_sort Lee, Eun Jung
collection PubMed
description PURPOSE: To investigate the differences in peripapillary vessel density (VD) between compressive optic neuropathy (CON) and normal-tension glaucoma (NTG). METHODS: We compared patients with chronic CON and NTG, particularly after strictly controlling the mean extent of macular damage by the area of the ganglion cell–inner plexiform layer (GCIPL) loss in optical coherence tomography (OCT). We compared retinal nerve fiber layer (RNFL) and GCIPL thickness from OCT and peripapillary and macular VD from OCT angiography (OCTA) between the CON and NTG groups. RESULTS: From the initial 184 patients with CON and 443 patients with OAG, we included 41 patients with CON (57 eyes) and 64 patients with NTG (75 eyes) with a comparable extent of macular GCIPL thinning. Under similar mean macular involvement, the peripapillary VD was significantly lower in the CON group than in the NTG group after considering the effects of age, spherical equivalent, visual field sensitivity, peripapillary RNFL (pRNFL) thickness, GCIPL thickness, and image quality scores (P < 0.001). Marked loss of VD in the temporal and nasal sectors in CON was notable, attributing to the significantly lower peripapillary VD compared to NTG. CONCLUSIONS: Patients with CON had a significantly lower peripapillary VD than those with NTG under similar mean degrees of pRNFL thickness and GCIPL damage. Our results reveal the potential utility of OCTA VD besides OCT pRNFL thickness, in relation to different topographic patterns of pRNFL loss, and possible differences in the pathogenesis of microvascular compromise between CON and NTG.
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spelling pubmed-104840182023-09-08 Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison Lee, Eun Jung Han, Jong Chul Kee, Changwon Park, Kyung-Ah Kong, Doo-Sik Hong, Sang Duk Invest Ophthalmol Vis Sci Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology PURPOSE: To investigate the differences in peripapillary vessel density (VD) between compressive optic neuropathy (CON) and normal-tension glaucoma (NTG). METHODS: We compared patients with chronic CON and NTG, particularly after strictly controlling the mean extent of macular damage by the area of the ganglion cell–inner plexiform layer (GCIPL) loss in optical coherence tomography (OCT). We compared retinal nerve fiber layer (RNFL) and GCIPL thickness from OCT and peripapillary and macular VD from OCT angiography (OCTA) between the CON and NTG groups. RESULTS: From the initial 184 patients with CON and 443 patients with OAG, we included 41 patients with CON (57 eyes) and 64 patients with NTG (75 eyes) with a comparable extent of macular GCIPL thinning. Under similar mean macular involvement, the peripapillary VD was significantly lower in the CON group than in the NTG group after considering the effects of age, spherical equivalent, visual field sensitivity, peripapillary RNFL (pRNFL) thickness, GCIPL thickness, and image quality scores (P < 0.001). Marked loss of VD in the temporal and nasal sectors in CON was notable, attributing to the significantly lower peripapillary VD compared to NTG. CONCLUSIONS: Patients with CON had a significantly lower peripapillary VD than those with NTG under similar mean degrees of pRNFL thickness and GCIPL damage. Our results reveal the potential utility of OCTA VD besides OCT pRNFL thickness, in relation to different topographic patterns of pRNFL loss, and possible differences in the pathogenesis of microvascular compromise between CON and NTG. The Association for Research in Vision and Ophthalmology 2023-09-06 /pmc/articles/PMC10484018/ /pubmed/37672287 http://dx.doi.org/10.1167/iovs.64.12.10 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
Lee, Eun Jung
Han, Jong Chul
Kee, Changwon
Park, Kyung-Ah
Kong, Doo-Sik
Hong, Sang Duk
Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title_full Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title_fullStr Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title_full_unstemmed Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title_short Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison
title_sort peripapillary vascular density in compressive optic neuropathy and normal-tension glaucoma: a severity-controlled comparison
topic Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484018/
https://www.ncbi.nlm.nih.gov/pubmed/37672287
http://dx.doi.org/10.1167/iovs.64.12.10
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