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Combining PD-1/PD-L1 blockade with type I interferon in cancer therapy

PD-1 and PD-L1 are crucial regulators of immunity expressed on the surface of T cells and tumour cells, respectively. Cancer cells frequently use PD-1/PD-L1 to evade immune detection; hence, blocking them exposes tumours to be attacked by activated T cells. The synergy of PD-1/PD-L1 blockade with ty...

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Detalles Bibliográficos
Autores principales: Razaghi, Ali, Durand-Dubief, Mickaël, Brusselaers, Nele, Björnstedt, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484344/
https://www.ncbi.nlm.nih.gov/pubmed/37691915
http://dx.doi.org/10.3389/fimmu.2023.1249330