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Germline-encoded specificities and the predictability of the B cell response

Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation. High-affinity antibodies to pathogens such as HIV, influenza, and SARS-CoV-2 are frequently reported to arise from B cells whose receptors, the...

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Detalles Bibliográficos
Autores principales: Vieira, Marcos C., Palm, Anna-Karin E., Stamper, Christopher T., Tepora, Micah E., Nguyen, Khoa D., Pham, Tho D., Boyd, Scott D., Wilson, Patrick C., Cobey, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484431/
https://www.ncbi.nlm.nih.gov/pubmed/37624867
http://dx.doi.org/10.1371/journal.ppat.1011603