Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold

Accurate protein-protein docking remains challenging, especially for artificial biologics not coevolved naturally against their protein targets, like antibodies and other engineered scaffolds. We previously developed ProPOSE, an exhaustive docker with full atomistic details, which delivers cutting-e...

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Detalles Bibliográficos
Autores principales: Gaudreault, Francis, Baardsnes, Jason, Martynova, Yuliya, Dachon, Aurore, Hogues, Hervé, Corbeil, Christopher R., Purisima, Enrico O., Arbour, Mélanie, Sulea, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484509/
https://www.ncbi.nlm.nih.gov/pubmed/37692063
http://dx.doi.org/10.3389/fmolb.2023.1253689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484509/
https://www.ncbi.nlm.nih.gov/pubmed/37692063
http://dx.doi.org/10.3389/fmolb.2023.1253689

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