EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. This study sought to investigate the role of the exch...

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Detalles Bibliográficos
Autores principales: Mazevet, Marianne, Belhadef, Anissa, Ribeiro, Maxance, Dayde, Delphine, Llach, Anna, Laudette, Marion, Belleville, Tiphaine, Mateo, Philippe, Gressette, Mélanie, Lefebvre, Florence, Chen, Ju, Bachelot-Loza, Christilla, Rucker-Martin, Catherine, Lezoualch, Frank, Crozatier, Bertrand, Benitah, Jean-Pierre, Vozenin, Marie-Catherine, Fischmeister, Rodolphe, Gomez, Ana-Maria, Lemaire, Christophe, Morel, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484526/
https://www.ncbi.nlm.nih.gov/pubmed/37551870
http://dx.doi.org/10.7554/eLife.83831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484526/
https://www.ncbi.nlm.nih.gov/pubmed/37551870
http://dx.doi.org/10.7554/eLife.83831

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